4-Methoxyphenyl boric acid → HCID 178476646, compound

HRID 2359890Notes

Reaction equation

HRID 2359890 reaction equation
Br[C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][N:7]([CH2:13][C:14]3[C:19]([O:20][CH3:21])=[CH:18][CH:17]=[CH:16][C:15]=3[O:22][CH3:23])[C:8]([NH2:12])=[N:9]2)=[CH:4][CH:3]=1.[CH3:24][O:25][C:26]1[CH:31]=[CH:30][C:29](OB(O)O)=[CH:28][CH:27]=1>>[C:19]([O-:20])(=[O:25])[CH3:14].[CH3:23][O:22][C:15]1[CH:16]=[CH:17][CH:18]=[C:19]([O:20][CH3:21])[C:14]=1[CH2:13][N:7]1[CH2:6][C:5]2[C:10](=[CH:11][C:2]([C:29]3[CH:30]=[CH:31][C:26]([O:25][CH3:24])=[CH:27][CH:28]=3)=[CH:3][CH:4]=2)[N:9]=[C:8]1[NH3+:12]

Participants

3

Reactant 2

HCID 147699944-Methoxyphenyl boric acidHCID 68546471HCID 68546471, compound

Product 1

HCID 178476646HCID 178476646, compound

Procedure

Synthesis was performed according to EXAMPLE 82 from 7-bromo-3-(2,6-dimethoxybenzyl)-3,4-dihydroquinazolin-2-amine and 4-methoxyphenylboric acid in a CEM microwave at 100° C. (120 watt) for 120 minutes.

Workup

  1. customSynthesis
  2. customfor 120 minutes

Sources & evidence

ORD record
ord-c0eebb39bea9419889a625f756bce11a
Source dataset
uspto-grants-2014_04
Patent number
US08686002B2

Reaction notes

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