Dichloromethane → HCID 68550184, compound

HRID 2359898Notes

Reaction equation

HRID 2359898 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[C:12](=[O:13])OC(=O)[NH:9][C:8]=2[CH:15]=1)([O-:3])=[O:2].[CH3:16][O:17][C:18]1[CH:25]=[CH:24][CH:23]=[CH:22][C:19]=1[CH2:20][NH2:21].C(Cl)Cl>C1(C)C=CC=CC=1>[NH2:9][C:8]1[CH:15]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=[CH:6][C:7]=1[C:12]([NH:21][CH2:20][C:19]1[CH:22]=[CH:23][CH:24]=[CH:25][C:18]=1[O:17][CH3:16])=[O:13]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 812922-MethoxybenzylamineHCID 2820894-Nitro-isatoic anhydride

Product 1

HCID 68550184HCID 68550184, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 9.3 g 7-nitro-1H-benzo[d][1.3]oxazine-2,4-dione (45 mmol) and 12.3 g 2-methoxybenzylamine (90 mmol) in 200 mL toluene was stirred for 30 minutes at reflux, then mixed with methylene chloride and washed repeated with water. The organic phase was dried, concentrated and the solid residue was dried and reacted further without further purification.

Workup

  1. temperatureat reflux
  2. washwashed
  3. customThe organic phase was dried
  4. concentrationconcentrated
  5. customthe solid residue was dried
  6. customreacted further without further purification

Sources & evidence

ORD record
ord-9d0f2b18ff764072a452d001ec07ccc6
Source dataset
uspto-grants-2014_04
Patent number
US08686002B2

Reaction notes

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