反应详情

温度

75 °C

Under argon, 3.17 g (11.7 mmol) of 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]pyridine, 2.02 g (11.7 mmol) of 6-bromopyridine-2-amine and 945 mg (817 μmol) of tetrakis(triphenylphosphine)palladium were added to a mixture, degassed by means of argon, of 23.3 ml of 2 M sodium carbonate solution in water and 63.3 ml of acetonitrile. The reaction mixture was heated to 75° C. for 18 hours, diluted with acetonitrile after cooling, dried over MgSO4, filtered and concentrated. The crude product thus obtained was purified by chromatography (acetonitrile/acetone).

1. customdegassed by means of argon, of 23.3 ml of 2 M sodium carbonate solution in water and 63.3 ml of acetonitrile
2. additiondiluted with acetonitrile
3. temperatureafter cooling
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated