Hydrogen chloride-ethyl acetate → HCID 67004062, compound

HRID 2359963Notes

Reaction equation

HRID 2359963 reaction equation
[CH3:1][N:2]([CH2:10][C:11]1[S:12][C:13]([S:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)(=[O:24])=[O:23])=[C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:15]=1)C(=O)OC(C)(C)C.C(OCC)(=O)C.[ClH:37]>C(O)C>[ClH:37].[CH3:1][NH:2][CH2:10][C:11]1[S:12][C:13]([S:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)(=[O:24])=[O:23])=[C:14]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[N:15]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 57687734HCID 57687734, compound

Product 1

HCID 67004062HCID 67004062, compoundYield 53%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of tert-butyl methyl{[4-phenyl-5-(phenylsulfonyl)-1,3-thiazol-2-yl]methyl}carbamate (0.18 g) in ethanol (2 mL) was added 4 mol/L hydrogen chloride-ethyl acetate solution (2 mL) at room temperature, and the mixture was stirred for 14 hr. The reaction mixture was concentrated under reduced pressure, and the residue was recrystallized from ethanol to give the title compound as white crystals (yield 80 mg, 53%).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-4846661d84674012a84ea235652e1950
Source dataset
uspto-grants-2014_04
Patent number
US08686010B2

Reaction notes

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