(S)-Methyl 4-(1-aminoethyl)benzoate hydrochloride → 4-[(1S)-1-[[3-(Difluoromethyl)-1-methyl-5-[3-(trifluoromethyl)phenoxy]pyrazole-4-carbonyl]amino]ethyl]benzoic acid

HRID 2359979Notes

Reaction equation

HRID 2359979 reaction equation
[F:1][CH:2]([F:23])[C:3]1[C:7]([C:8]([OH:10])=O)=[C:6]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[N:5]([CH3:22])[N:4]=1.Cl.[NH2:25][C@H:26]([C:28]1[CH:37]=[CH:36][C:31]([C:32]([O:34]C)=[O:33])=[CH:30][CH:29]=1)[CH3:27]>>[CH3:27][C@H:26]([NH:25][C:8]([C:7]1[C:3]([CH:2]([F:23])[F:1])=[N:4][N:5]([CH3:22])[C:6]=1[O:11][C:12]1[CH:13]=[C:14]([C:18]([F:19])([F:21])[F:20])[CH:15]=[CH:16][CH:17]=1)=[O:10])[C:28]1[CH:29]=[CH:30][C:31]([C:32]([OH:34])=[O:33])=[CH:36][CH:37]=1

Participants

3

Reactant 2

HCID 57462942(S)-Methyl 4-(1-aminoethyl)benzoate hydrochlorideHCID 66826025HCID 66826025, compound

Product 1

HCID 569447054-[(1S)-1-[[3-(Difluoromethyl)-1-methyl-5-[3-(trifluoromethyl)phenoxy]pyrazole-4-carbonyl]amino]ethyl]benzoic acid

Procedure

Example 21 was prepared using 3-(difluoromethyl)-1-methyl-5-(3-(trifluoromethyl)phenoxy)-1H-pyrazole-4-carboxylic acid and (S)-methyl 4-(1-aminoethyl)benzoate hydrochloride in a manner similar to the Example 4 above.

Workup

  1. customExample 21 was prepared

Sources & evidence

ORD record
ord-0c1b9050eec8490bbfb9974bf62802e8
Source dataset
uspto-grants-2014_04
Patent number
US08686018B2

Reaction notes

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