1H-Imidazole, 4,5-dihydro-2-(methylthio)-, hydriodide (1:1) → HCID 178432365, compound

HRID 235999Notes

Reaction equation

HRID 235999 reaction equation
I.[CH3:2]C1C(C)NC(SC)=N1.I.CSC1NCCN=1.[NH2:19][C:20]1[N:21]([CH2:34][C:35]2[CH:40]=[CH:39][C:38]([Cl:41])=[CH:37][CH:36]=2)[C:22]2[N:23]([CH:29]([CH3:33])[CH:30]([CH3:32])[N:31]=2)[C:24](=[O:28])[C:25]=1[N:26]=O>>[Cl:41][C:38]1[CH:39]=[CH:40][C:35]([CH2:34][N:21]2[C:20]3[NH:19][CH:2]=[N:26][C:25]=3[C:24](=[O:28])[N:23]3[CH:29]([CH3:33])[CH:30]([CH3:32])[N:31]=[C:22]23)=[CH:36][CH:37]=1

Participants

4

Reactant 3

HCID 122212281H-Imidazole, 4,5-dihydro-2-(methylthio)-, hydriodide (1:1)HCID 202177174,5-Dimethyl-2-(methylthio)-2-imidazoline hydroiodideHCID 178432366HCID 178432366, compound

Product 1

HCID 178432365HCID 178432365, compound

Procedure

Procedure 1 is repeated with substitution of 4,5-dimethyl-2-(methylthio)-2-imidazoline hydroiodide for the 2-(methylthio)-2-imidazoline hydroiodide specified. The resulting 7-amino-2,3-dihydro-2,3-dimethyl-8-[(4-chlorphenyl)methyl]-6-nitrosoimidazo[1,2-a]pyrimidin-5(8H)-one is converted to the corresponding 6-formylamino compound by the method of Procedure 2 and the latter is converted to the desired product by the method of Procedure 4.

Sources & evidence

ORD record
ord-4ede1eb731ee47aea7232f748cfc1550
Source dataset
uspto-grants-1987_02
Patent number
US04642345

Reaction notes

Loading…