Water → HCID 57419441, compound

HRID 2359997Notes

Reaction equation

HRID 2359997 reaction equation
[C:1]([C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:6]=1[OH:14])([CH3:4])([CH3:3])[CH3:2].O.[I:16]Cl>CO>[C:1]([C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[C:7]([I:16])[C:6]=1[OH:14])([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 962Water2×HCID 24640Iodine chlorideHCID 5289442-tert-butyl-4-nitrophenol

Product 1

HCID 57419441HCID 57419441, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To the product from Example 1, Part A (4.5 g, 23.05 mmol) dissolved in MeOH (120 ml) and water (30 mL) was added iodine monochloride (1.155 ml, 23.05 mmol) drop wise over a period of 10 min. The mixture was stirred for 2 h and diluted into 1 L of water and allowed to stand overnight. The solid material was collected by filtration and washed 3×50 mL with water and dried under vacuum overnight to give a tan solid (7.14 g, 96%).

Workup

  1. waitto stand overnight
  2. filtrationThe solid material was collected by filtration
  3. washwashed 3×50 mL with water
  4. customdried under vacuum overnight

Sources & evidence

ORD record
ord-2bdd17a938ac4e86abf41e4f195d597a
Source dataset
uspto-grants-2014_04
Patent number
US08685991B2

Reaction notes

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