Pyridine → HCID 67066356, compound

HRID 2360000Notes

Reaction equation

HRID 2360000 reaction equation
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.N1C=CC=CC=1.[CH3:15][O:16]/[CH:17]=[CH:18]/[C:19](Cl)=[O:20]>C(Cl)Cl>[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:19](=[O:20])/[CH:18]=[CH:17]/[O:16][CH3:15])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 78074-BromoanilineHCID 10154044HCID 10154044, compound

Product 1

HCID 67066356HCID 67066356, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Combined 4-bromoaniline (285 mg, 1.659 mmol), CH2Cl2 (2.0 ml) and pyridine (0.25 ml, 3.09 mmol) and slowly added (E)-3-methoxyacryloyl chloride (200 mg, 1.659 mmol) sand stirred at room temperature for 2 h. The resulting yellow solid was filtered off and washed with water. The solid was dried under vacuum to give the title compound (406 mg, 96%).

Workup

  1. filtrationThe resulting yellow solid was filtered off
  2. washwashed with water
  3. customThe solid was dried under vacuum

Sources & evidence

ORD record
ord-67bbc76f3de04dd28ca6ce26b5d214c5
Source dataset
uspto-grants-2014_04
Patent number
US08685991B2

Reaction notes

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