Water → HCID 12683867, compound

HRID 236003Notes

Reaction equation

HRID 236003 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]2[C:17]3[NH:16][CH:15]=[N:14][C:13]=3[C:12](=[O:18])[N:11]3[CH2:19][CH2:20][N:21]=[C:10]23)=[CH:4][CH:3]=1.O.[OH-].[Na+].[CH3:25]I>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]2[C:17]3[N:16]=[CH:15][N:14]([CH3:25])[C:13]=3[C:12](=[O:18])[N:11]3[CH2:19][CH2:20][N:21]=[C:10]23)=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 962WaterHCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 178515261HCID 178515261, compound

Product 1

HCID 12683867HCID 12683867, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-[(4-Chlorophenyl)methyl]-6,7-dihydro-3H-imidazo-[1,2-a]purin -9(4H)-one (Procedure 3), 6.02 g. (0.02 mole), is dissolved with warming in a mixture of 100 ml. of water and 15 ml. of ethanol containing 1.0 g. (0.25 mole) of sodium hydroxide. Approximately 3 ml. (approximately a molar equivalent) of methyl iodide was added and the mixture was stirred for about 48 hrs. at room temperature. The precipitated solid was collected, air dried, and recrystallized from isopropanol, m.p. 182.5°-184.5°.

Workup

  1. dissolution(0.02 mole), is dissolved
  2. temperaturewith warming in a mixture of 100 ml
  3. customat room temperature
  4. customThe precipitated solid was collected
  5. customair dried
  6. customrecrystallized from isopropanol, m.p. 182.5°-184.5°

Sources & evidence

ORD record
ord-4b63e0ec9bd2485cb426aeea7cb7febb
Source dataset
uspto-grants-1987_02
Patent number
US04642345

Reaction notes

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