Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Citric Acid | HCID 311 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sunitinib | HCID 5329102 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 86658825 | HCID 86658825 | — |
Reaction Steps
In another example sunitinib base and molar equivalent of citric acid are dissolved, while heating, in the mixture of methanol and water, preferably in 1:1 volumetric ratio. The solution is subsequently left to cool to about room temperature such as about 20 to 25° C. to give sunitinib citrate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08686023B2 |
|---|
| Source dataset | uspto-grants-2014_04 |
|---|
| ORD ID | ord-d8a856ad41474fdfa952f3be0da74a24 |
|---|
| Source note | uspto-grants-2014_04 |
|---|
