Citric Acid → HCID 86658825, compound

HRID 2360067Notes

Reaction equation

HRID 2360067 reaction equation
[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:15]([CH3:16])=[C:14](/[CH:17]=[C:18]2/[C:19]3[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=3[NH:26][C:27]/2=[O:28])[NH:13][C:12]=1[CH3:29])=[O:10])[CH2:4][CH3:5].[C:30]([OH:42])(=[O:41])[CH2:31][C:32]([CH2:37][C:38]([OH:40])=[O:39])([C:34]([OH:36])=[O:35])[OH:33]>C(O)C>[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:15]([CH3:16])=[C:14](/[CH:17]=[C:18]2/[C:19]3[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=3[NH:26][C:27]/2=[O:28])[NH:13][C:12]=1[CH3:29])=[O:10])[CH2:4][CH3:5].[C:30]([O-:42])(=[O:41])[CH2:31][C:32]([CH2:37][C:38]([O-:40])=[O:39])([C:34]([O-:36])=[O:35])[OH:33]

Participants

4

Reactant 2

HCID 311Citric AcidHCID 5329102Sunitinib

Product 1

HCID 86658825HCID 86658825, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
22.5 °C

Procedure

In yet another example sunitinib base is dissolved in boiling ethanol, subsequently citric acid is added to the solution, which is then left to cool to about room temperature such as about 20 to 25° C. to give sunitinib citrate.

Workup

  1. additionis added to the solution, which
  2. waitis then left

Sources & evidence

ORD record
ord-fc6844f523124c6cba4c89edd2507819
Source dataset
uspto-grants-2014_04
Patent number
US08686023B2

Reaction notes

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