HCID 20217711, compound → HCID 178448427, compound

HRID 236007Notes

Reaction equation

HRID 236007 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][C:10]2[N:11]([CH2:20][CH:21]([CH3:23])[CH3:22])[C:12]3[N:13]([CH2:17][CH2:18][N:19]=3)[C:14](=[O:16])[CH:15]=2)=[CH:4][CH:3]=1.[N:24]([O-])=[O:25].[Na+]>C(O)(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][C:10]2[N:11]([CH2:20][CH:21]([CH3:23])[CH3:22])[C:12]3[N:13]([CH2:17][CH2:18][N:19]=3)[C:14](=[O:16])[C:15]=2[N:24]=[O:25])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 20217711HCID 20217711, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 178448427HCID 178448427, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
0 °C

Procedure

A suspension of the product of Procedure 86 (0.1 mol) in 150 ml. 25% aqueous acetic acid is cooled to 0° C. and treated by dropwise addition of an aqueous solution of sodium nitrite (0.11 mol). After stirring at 0° C. for an hour, the mixture is warmed to room temperature, the solid collected by filtration, washed with water and air dried.

Workup

  1. temperaturethe mixture is warmed to room temperature
  2. filtrationthe solid collected by filtration
  3. washwashed with water and air
  4. customdried

Sources & evidence

ORD record
ord-c11a32740cbe4e76a53db09c7470f0f2
Source dataset
uspto-grants-1987_02
Patent number
US04642345

Reaction notes

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