HuagongsheHuagongshe Chemistry Print Report · For research reference only
Citric Acid → 5-fluoro-1,3-dihydro-2H-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Citric Acid | HCID 311 | — |
| Reactant | Sunitinib | HCID 5329102 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-fluoro-1,3-dihydro-2H-indol-2-one | HCID 3731012 | — |
| Product | HCID 86658825 | HCID 86658825 | — |
Reaction Steps
Sunitinib (1.19 g, 2.99 mmol) dissolved in ethanol (120 ml) and citric acid (0.63 g, 3.29 mmol) dissolved in ethanol (10 ml) were combined while heating, and left to cool to room temperature to give sunitinib citrate with melting points 167-173° C. (Form I), 185-198° C. (Form II) and 215-222° C. (Form III).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08686023B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-d7cc5c5ce27a44d2887bfa086267858f |
| Source note | uspto-grants-2014_04 |