HCID 67078793, compound → HCID 67078730, compound

Participants

Reaction Steps

This material was prepared using a method substantially similar to that of Example 5 from 3-(4-fluorophenyl)-5-(2-thienyl)-1H-pyrrole-2-carboxylic acid and methyl 5-(aminomethyl)pyrazine-2-carboxylate hydrochloride, yielding the title compound. Methyl 5-[({[3-(4-fluorophenyl)-5-(2-thienyl)-1H-pyrrol-2-yl]carbonyl}amino)methyl]pyrazine-2-carboxylate: Yield 76%; 1H-NMR (500 MHz, δ ppm, CDCl3) 9.47 (sb, 1H), 9.07 (s, 1H), 8.64 (s, 1H), 7.47 (dd, J=8.3 Hz, J′=5.5 Hz, 2H), 7.24 (d, J=4.5 Hz, 1H), 7.21 (d, J=3.0 Hz, 1H), 7.16 (t, J=8.6 Hz, 2H), 7.06 (dd, J=4.5 Hz, J′=4.1 Hz, 1H), 6.64 (t, J=4.6 Hz, 1H), 6.40 (d, J=2.9 Hz, 1H), 4.72 (d, J=5.2 Hz, 2H), 4.04 (s, 3H).

Provenance & Evidence