Hydrochloric Acid → HCID 46195897, compound

Participants

Reaction Steps

To a stirred solution of 7-hydroxy-3-(2-hydroxy-phenyl)-8-methyl-chromen-4-one (3 gm, 11.2 mmol) in absolute ethanol (30 ml) at 0° C. was added NaBH4 (2.6 gm, 67.2 mmol). The reaction mixture was then stirred for 24 hours at room temperature. The reaction was stopped by adding ice-cooled water and the solution was neutralized with 10% HCl to get the white precipitate. The white precipitate was washed with water and the purified by silica gel column chromatography using hexane-chloroform as the eluent to give 4-methyl-6a,11a-dihydro-6H-benzo[4,5]furo[3,2-c]chromen-3-ol (1.56 gm, 55%) as white solid.

Provenance & Evidence