(S)-(-)-1-Phenylethyl isocyanate → HCID 46866236, compound

HRID 2360133Notes

Reaction equation

HRID 2360133 reaction equation
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([OH:17])=[CH:14][CH:15]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:18][C@H:19]([N:26]=[C:27]=[O:28])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[C:20]1([C@@H:19]([NH:26][C:27](=[O:28])[O:17][C:13]2[CH:12]=[C:11]3[C:16](=[CH:15][CH:14]=2)[N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:9][CH2:10]3)[CH3:18])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 2724173(S)-(-)-1-Phenylethyl isocyanateHCID 866598571-Benzylindolin-5-ol

Product 1

HCID 46866236HCID 46866236, compound

Procedure

The title compound was synthesized from 1-benzylindolin-5-ol (35.0 mg, 0.155 mmol) using the same procedure employed for Example 2 (2), but with (S)-α-methylbenzylisocyanate instead of 4-isopropylphenylisocyanate. The product was obtained as a white solid (14.8 mg, 27%) having the following characteristics.

Sources & evidence

ORD record
ord-172ecb15dce14a0bbe147e4f06a88a3f
Source dataset
uspto-grants-2014_04
Patent number
US08686024B2

Reaction notes

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