Cyclohexyl isocyanate → HCID 46866045, compound

HRID 2360134Notes

Reaction equation

[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([OH:17])=[CH:14][CH:15]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:18]1([N:24]=[C:25]=[O:26])[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1>>[CH:18]1([NH:24][C:25](=[O:26])[O:17][C:13]2[CH:12]=[C:11]3[C:16](=[CH:15][CH:14]=2)[N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:9][CH2:10]3)[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1

Participants

Reactant 2

HCID 18502Cyclohexyl isocyanate

HCID 866598571-Benzylindolin-5-ol

Product 1

HCID 46866045HCID 46866045, compound

Procedure

The title compound was synthesized from 1-benzylindolin-5-ol (35.0 mg, 0.155 mmol) using the same procedure employed for Example 2 (2), but with cyclohexylisocyanate instead of 4-isopropylphenylisocyanate. The product was obtained as a white solid (14.8 mg, 27%) having the following characteristics.

Sources & evidence

ORD record: ord-7f0de3d62ae94fcbab0c46840dd59b2d
Source dataset: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08686024B2

Reaction notes

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