4-Methoxybenzylamine → HCID 86659867, compound

Participants

Reaction Steps

To a solution of 1-benzylindolin-5-ol (15.0 mg, 66.6 μmol) in 0.50 mL of dry dichloromethane was added triphosgene (6.9 mg, 23 μmol) and N,N-diisopropylethylamine (14 μL, 82 μmol), successively. After the reaction mixture was stirred at room temperature for 10 min, 4-methoxybenzylamine (17 μL, 0.13 mmol) was added. After the reaction mixture was stirred at the same temperature for 30 min, the reaction mixture was diluted with hexane (1 mL) and 1 M HCl (2 mL). The organic layer was purified directly by silica gel column chromatography (eluting with hexane/ethyl acetate or chloroform/methanol) to obtain the title compound as a white solid (6.1 mg, 24%).

Provenance & Evidence