3-(Trifluoromethyl)phenyl isocyanate → HCID 86659870, compound

HRID 2360142Notes

Reaction equation

HRID 2360142 reaction equation
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([OH:17])=[CH:14][CH:15]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:18][C:19]([F:30])([F:29])[C:20]1[CH:21]=[C:22]([N:26]=[C:27]=[O:28])[CH:23]=[CH:24][CH:25]=1>>[F:18][C:19]([F:29])([F:30])[C:20]1[CH:21]=[C:22]([NH:26][C:27](=[O:28])[O:17][C:13]2[CH:12]=[C:11]3[C:16](=[CH:15][CH:14]=2)[N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:9][CH2:10]3)[CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 94833-(Trifluoromethyl)phenyl isocyanateHCID 866598571-Benzylindolin-5-ol

Product 1

HCID 86659870HCID 86659870, compound

Procedure

The title compound was synthesized from 1-benzylindolin-5-ol (15.0 mg, 66.6 μmol) using the same procedure employed for Example 1 (2), but with 3-trifluoromethylphenylisocyanate instead of 4-isopropylphenylisocyanate. The product was obtained as a sticky oil (1.2 mg, 4%) having the following characteristics.

Sources & evidence

ORD record
ord-0e7a3f33a224461488938848b0d505fe
Source dataset
uspto-grants-2014_04
Patent number
US08686024B2

Reaction notes

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