4-Biphenylyl isocyanate → HCID 86659871, compound

HRID 2360143Notes

Reaction equation

HRID 2360143 reaction equation
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([OH:17])=[CH:14][CH:15]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:18]1([C:24]2[CH:29]=[CH:28][C:27]([N:30]=[C:31]=[O:32])=[CH:26][CH:25]=2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[C:18]1([C:24]2[CH:29]=[CH:28][C:27]([NH:30][C:31](=[O:32])[O:17][C:13]3[CH:12]=[C:11]4[C:16](=[CH:15][CH:14]=3)[N:8]([CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH2:9][CH2:10]4)=[CH:26][CH:25]=2)[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 36123194-Biphenylyl isocyanateHCID 866598571-Benzylindolin-5-ol

Product 1

HCID 86659871HCID 86659871, compound

Procedure

The title compound was synthesized from 1-benzylindolin-5-ol (15.0 mg, 66.6 μmol) using the same procedure employed for Example 1 (2), but with 4-phenylphenylisocyanate instead of 4-isopropylphenylisocyanate. The product was obtained as a white solid (0.9 mg, 3%) having the following characteristics.

Sources & evidence

ORD record
ord-980825845fdf42a2af66b6292bd9a1ae
Source dataset
uspto-grants-2014_04
Patent number
US08686024B2

Reaction notes

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