3,4-Dimethylphenyl isocyanate → HCID 46865059, compound

HRID 2360145Notes

Reaction equation

HRID 2360145 reaction equation
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([OH:17])=[CH:14][CH:15]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:18][C:19]1[CH:20]=[C:21]([N:26]=[C:27]=[O:28])[CH:22]=[CH:23][C:24]=1[CH3:25]>>[CH3:18][C:19]1[CH:20]=[C:21]([NH:26][C:27](=[O:28])[O:17][C:13]2[CH:12]=[C:11]3[C:16](=[CH:15][CH:14]=2)[N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:9][CH2:10]3)[CH:22]=[CH:23][C:24]=1[CH3:25]

Participants

3

Reactant 2

HCID 43896633,4-Dimethylphenyl isocyanateHCID 866598571-Benzylindolin-5-ol

Product 1

HCID 46865059HCID 46865059, compound

Procedure

The title compound was synthesized from 1-benzylindolin-5-ol (15.0 mg, 66.6 μmol) using the same procedure employed for Example 2 (2), but with 3,4-dimethylphenylisocyanate instead of 4-isopropylphenylisocyanate. The product was obtained as a sticky oil (10.5 mg, 42%) having the following characteristics.

Sources & evidence

ORD record
ord-7ecd313c976a4619b471561abd872847
Source dataset
uspto-grants-2014_04
Patent number
US08686024B2

Reaction notes

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