Propyl isocyanate → HCID 46865060, compound

HRID 2360146Notes

Reaction equation

[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([OH:17])=[CH:14][CH:15]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:18]([N:21]=[C:22]=[O:23])[CH2:19][CH3:20]>>[CH2:18]([NH:21][C:22](=[O:23])[O:17][C:13]1[CH:12]=[C:11]2[C:16](=[CH:15][CH:14]=1)[N:8]([CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[CH2:9][CH2:10]2)[CH2:19][CH3:20]

Participants

Reactant 2

HCID 61033Propyl isocyanate

HCID 866598571-Benzylindolin-5-ol

Product 1

HCID 46865060HCID 46865060, compound

Procedure

The title compound was synthesized from 1-benzylindolin-5-ol (15.0 mg, 66.6 μmol) using the same procedure employed for Example 2 (2), but with n-propylisocyanate instead of 4-isopropylphenylisocyanate. The product was obtained as a white solid (12.3 mg, 60%) having the following characteristics.

Sources & evidence

ORD record: ord-ff7c124071c44082a40968dfb8269602
Source dataset: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08686024B2

Reaction notes

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