HCID 46865173, compound → HCID 86659874, compound

HRID 2360148Notes

Reaction equation

HRID 2360148 reaction equation
[CH3:1][N:2]([CH3:29])[C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:28])[O:11][C:12]2[CH:13]=[C:14]3[C:18](=[CH:19][CH:20]=2)[N:17](CC2C=CC=CC=2)[CH2:16][CH2:15]3)=[CH:5][CH:4]=1>C(Cl)(Cl)Cl.CO>[CH3:1][N:2]([CH3:29])[C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10](=[O:28])[O:11][C:12]2[CH:13]=[C:14]3[C:18](=[CH:19][CH:20]=2)[NH:17][CH2:16][CH2:15]3)=[CH:7][CH:8]=1

Participants

3

Reactant 1

HCID 46865173HCID 46865173, compound

Product 1

HCID 86659874HCID 86659874, compound

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

The title compound was synthesized from 1-benzylindolin-5-yl 4-dimethylaminophenylcarbamate (30 mg, 77 μmol) using the same procedure employed for Example 123 (silica gel column chromatography: chloroform/methanol=99/1 to 90/10). The product was obtained as a white solid (4.0 mg, 17%) having the following characteristics.

Sources & evidence

ORD record
ord-31c020b87bf34c56a8b688c9fa9add19
Source dataset
uspto-grants-2014_04
Patent number
US08686024B2

Reaction notes

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