HCID 86739794, compound → HCID 20217719, compound

HRID 236015Notes

Reaction equation

HRID 236015 reaction equation
[I-].ClC1C=CC(C[N:10]2[C:18]3[N:17]=[CH:16][NH+:15]([CH3:19])[C:14]=3[C:13](=[O:20])[N:12]3[CH2:21][CH2:22][N:23]([CH3:24])[CH:11]23)=CC=1>[Pd].CCO>[CH3:19][N:15]1[C:14]2[C:13](=[O:20])[N:12]3[CH2:21][CH2:22][N:23]([CH3:24])[C:11]3=[N:10][C:18]=2[N:17]=[CH:16]1

Participants

4

Reactant 1

HCID 86739794HCID 86739794, compound

Product 1

HCID 20217719HCID 20217719, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of the quaternary salt of Procedure 94 and 10% palladium on carbon in abs. EtOH is subjected to hydrogenolysis at a pressure of about 50 psig. The spent catalyst is removed by filtration, the filtrate concentrated in vacuo, and the residue dissolved in water. Treatment with concentrated NH4OH liberates the free base which is collected and dried.

Workup

  1. customThe spent catalyst is removed by filtration
  2. concentrationthe filtrate concentrated in vacuo
  3. dissolutionthe residue dissolved in water
  4. customis collected
  5. customdried

Sources & evidence

ORD record
ord-87aa87e178fc47c89616a9efdb18247c
Source dataset
uspto-grants-1987_02
Patent number
US04642345

Reaction notes

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