1-Tert-butyl-4-isocyanatobenzene → HCID 86659875, compound

HRID 2360151Notes

Reaction equation

HRID 2360151 reaction equation
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([OH:17])=[CH:14][CH:15]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:18]([C:22]1[CH:27]=[CH:26][C:25]([N:28]=[C:29]=[O:30])=[CH:24][CH:23]=1)([CH3:21])([CH3:20])[CH3:19]>>[C:18]([C:22]1[CH:27]=[CH:26][C:25]([NH:28][C:29](=[O:30])[O:17][C:13]2[CH:12]=[C:11]3[C:16](=[CH:15][CH:14]=2)[N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:9][CH2:10]3)=[CH:24][CH:23]=1)([CH3:21])([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 27356951-Tert-butyl-4-isocyanatobenzeneHCID 866598571-Benzylindolin-5-ol

Product 1

HCID 86659875HCID 86659875, compound

Procedure

The title compound was synthesized from 1-benzylindolin-5-ol (50.0 mg, 0.222 mmol) using the same procedure employed for Example 2 (2), but with 4-tert-butylphenylisocyanate instead of 4-isopropylphenylisocyanate. The product was obtained as a white solid (34.1 mg, 38%) having the following characteristics.

Sources & evidence

ORD record
ord-e4f3c5d8c2bf46a5a97edecb0a711709
Source dataset
uspto-grants-2014_04
Patent number
US08686024B2

Reaction notes

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