4-Isocyanato-1,2-dimethoxybenzene → HCID 46865280, compound

HRID 2360152Notes

Reaction equation

HRID 2360152 reaction equation
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([OH:17])=[CH:14][CH:15]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:18][O:19][C:20]1[CH:21]=[C:22]([N:28]=[C:29]=[O:30])[CH:23]=[CH:24][C:25]=1[O:26][CH3:27]>>[CH3:18][O:19][C:20]1[CH:21]=[C:22]([NH:28][C:29](=[O:30])[O:17][C:13]2[CH:12]=[C:11]3[C:16](=[CH:15][CH:14]=2)[N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:9][CH2:10]3)[CH:23]=[CH:24][C:25]=1[O:26][CH3:27]

Participants

3

Reactant 2

HCID 35178104-Isocyanato-1,2-dimethoxybenzeneHCID 866598571-Benzylindolin-5-ol

Product 1

HCID 46865280HCID 46865280, compound

Procedure

The title compound was synthesized from 1-benzylindolin-5-ol (30.0 mg, 0.133 mmol) using the same procedure employed for Example 2 (2), but with 3,4-dimethoxyphenylisocyanate instead of 4-isopropylphenylisocyanate. The product was obtained as a white solid (26.9 mg, 50%) having the following characteristics.

Sources & evidence

ORD record
ord-54dd60880869453bbaf0db3e70e1f56a
Source dataset
uspto-grants-2014_04
Patent number
US08686024B2

Reaction notes

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