HCID 86659877, compound → HCID 86659878, compound

Participants

Reaction Steps

A solution of 1-[N-benzyl-N-(4-methoxyphenyl)amino]propan-2-on (863 mg, 3.20 mmol) in 9.6 mL of ethanol was added zinc chloride (1.3 g, 9.6 mmol) at room temperature. After the reaction mixture was stirred over night, zinc chloride (1.3 g, 9.6 mmol) was added with additional stirring for 10 h. After the reaction mixture was concentrated in vacuo, the residue was diluted with ethyl acetate, and washed with water, 1 M HCl, saturated NaHCO3 aqueous solution and brine, successively, and dried over MgSO4. After filtration, the filtrate was concentrated in vacuo, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate=95/5 to 80/20) to obtain the title compound (503 mg, 62%).

Provenance & Evidence