Hexyl isocyanate → HCID 46865283, compound

Participants

Reaction Steps

To a solution of 1-(2-pyridylmethyl)indolin-5-ol (20 mg, 88 μmol) in 0.5 mL of diethyl ether was added a piece of sodium (1 mg to 10 mg) at room temperature. After the reaction mixture was stirred at the same temperature for 2 min, n-hexylisocyanate (15 μL, 0.11 mmol, 1.2 equivalent) was added with additional stirring for 5 min to 10 min. After removal of sodium, the filtrate was concentrated in vacuo, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate=80/20 to 30/70) to obtain the title compound (21.2 mg, 68%) as a slightly brown solid.

Provenance & Evidence