HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dipropylamine → HCID 86659888, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dipropylamine | HCID 8902 | — |
| Reactant | 5-Methoxyindole-2-carboxylic acid | HCID 20401 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86659888 | HCID 86659888 | 74% |
Reaction Steps
To a solution of 5-methoxyindole-2-carboxylic acid (500 mg, 2.62 mmol) in 13 mL of N,N-dimethylformamide was added di-n-propylamine (1.07 mL, 7.8 mmol) and HATU (1.09 g, 2.88 mmol) at 0° C. After the reaction mixture was stirred at room temperature for 12 h, the reaction mixture was diluted with diethyl ether, and washed with water and brine, and dried over MgSO4. After filtration, the filtrate was concentrated in vacuo, and the residue was purified by silica gel column chromatography to obtain the title compound (0.53 g, 74%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08686024B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-c42f36d5f7df4ff3828a721200b321e8 |
| Source note | uspto-grants-2014_04 |