Methyl iodide → HCID 178503360, compound

HRID 236017Notes

Reaction equation

HRID 236017 reaction equation
O.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][N:10]2[C:18]3[NH:17][C:16](=[S:19])[NH:15][C:14]=3[C:13](=[O:20])[N:12]3[CH2:21][CH2:22][N:23]=[C:11]23)=[CH:5][CH:4]=1.I[CH3:25]>[OH-].[Na+]>[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][N:10]2[C:18]3[NH:17][C:16]([S:19][CH3:25])=[N:15][C:14]=3[C:13](=[O:20])[N:12]3[CH2:21][CH2:22][NH:23][CH:11]23)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 202177034-[(4-CHLOROPHENYL)METHYL]-2,3,6,7-TETRAHYDRO-2-THIOXO-1H-IMIDAZO[1,2-a]PURIN-9(4H)-ONE MONOHYDRATE

Product 1

HCID 178503360HCID 178503360, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

To a solution of the product of Procedure 97 (2.4 g., 0.0068 mole) in 0.1N NaOH (85 ml.), iodomethane (1.94 g., 0.0136 mole) was added and the mixture stirred at room temperature for 16 hrs. The insolubles were collected and recrystallized from methoxyethanol to give 1.3 g. of product, m.p. 296°-297°.

Workup

  1. customThe insolubles were collected
  2. customrecrystallized from methoxyethanol
  3. customto give 1.3 g

Sources & evidence

ORD record
ord-602c6d88f457400e91dd00279fb24ddf
Source dataset
uspto-grants-1987_02
Patent number
US04642345

Reaction notes

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