4-(Dimethylamino)phenyl isocyanate → HCID 86659903, compound

HRID 2360179Notes

Reaction equation

HRID 2360179 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][N:8]2[C:16]3[C:11](=[CH:12][C:13]([OH:17])=[CH:14][CH:15]=3)[C:10]([CH3:19])([CH3:18])[CH2:9]2)[CH:2]=1.[CH3:20][N:21]([CH3:31])[C:22]1[CH:27]=[CH:26][C:25]([N:28]=[C:29]=[O:30])=[CH:24][CH:23]=1>>[CH3:20][N:21]([CH3:31])[C:22]1[CH:27]=[CH:26][C:25]([NH:28][C:29](=[O:30])[O:17][C:13]2[CH:12]=[C:11]3[C:16](=[CH:15][CH:14]=2)[N:8]([CH2:7][C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)[CH2:9][C:10]3([CH3:19])[CH3:18])=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 27333724-(Dimethylamino)phenyl isocyanateHCID 86659898HCID 86659898, compound

Product 1

HCID 86659903HCID 86659903, compound

Procedure

The title compound was synthesized from 1-(3-pyridylmethyl)-3,3-dimethylindolin-5-ol (20.0 mg, 0.09 mmol) using the same procedure employed for Example 2 (2), but with 4-dimethylaminophenylisocyanate instead of 4-isopropylphenylisocyanate. The product was obtained as a white solid (4.7 mg, 14%) having the following characteristics.

Sources & evidence

ORD record
ord-6700c9a74475464f95604595218db111
Source dataset
uspto-grants-2014_04
Patent number
US08686024B2

Reaction notes

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