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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2360276Generated: November 2, 2026

4-(2-(4-Methyl-3-nitrophenoxy)ethyl)morpholine → 2-Methyl-5-[2-(morpholin-4-yl)ethoxy]aniline

https://huagongshe.com/reaction/2360276

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(2-(4-Methyl-3-nitrophenoxy)ethyl)morpholineHCID 58929867—
CatalystPalladiumHCID 23938—
SolventMethanolHCID 887—
Product2-Methyl-5-[2-(morpholin-4-yl)ethoxy]anilineHCID 39335039—

Reaction Steps

To the mixture of 4-(2-(4-methyl-3-nitrophenoxy)ethyl)morpholine (532 mg, 2 mmol) in MeOH (50 mL) was added 10% Pd/C (250 mg). The mixture was stirred under an atmosphere of H2 (balloon) overnight. The contents of the reaction mixture were then filtered and concentrated in vacuo to give the title product, which was used without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08686011B2
Source datasetuspto-grants-2014_04
ORD IDord-385118c164254ec5886257b7e6f813e1
Source noteuspto-grants-2014_04