Water → HCID 58929570, compound

HRID 2360281Notes

Reaction equation

HRID 2360281 reaction equation
C([NH:9][C:10]([NH:12][CH2:13][CH:14]1[CH2:19][CH:18]2[CH2:20][CH:15]1[CH2:16][CH2:17]2)=[S:11])(=O)C1C=CC=CC=1.[OH-].[K+].O>CO>[CH:15]12[CH2:20][CH:18]([CH2:17][CH2:16]1)[CH2:19][CH:14]2[CH2:13][NH:12][C:10]([NH2:9])=[S:11]

Participants

5

Reactant 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 58930363HCID 58930363, compound

Product 1

HCID 58929570HCID 58929570, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A 250 mL round-bottomed flask equipped with a magnetic stir bar was charged with 6.17 g (22.4 mmol) of 1-benzoyl-3-(bicyclo[2.2.1]heptan-2-ylmethyl)thiourea in 30 mL of MeOH. KOH was added (2.55 g, 45.4 mmol) and the reaction was stirred at ambient temperature for 4 h. Water (150 mL) was then added to the reaction mixture, and the solid was removed by filtration. The flask and filter cake were rinsed with 40 mL of H2O. The collected solid was then suspended in 15 mL of MTBE, and the solid was collected by filtration providing the desired thiourea. MS (ESI, pos. ion) m/z: 185.2 (M+H).

Workup

  1. customA 250 mL round-bottomed flask equipped with a magnetic stir bar
  2. customthe solid was removed by filtration
  3. filtrationThe flask and filter cake
  4. washwere rinsed with 40 mL of H2O
  5. filtrationthe solid was collected by filtration

Sources & evidence

ORD record
ord-501415c98d2447679d1b65532a8eb4e4
Source dataset
uspto-grants-2014_04
Patent number
US08686011B2

Reaction notes

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