Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 1,2-Diaminobenzene (D4, 98%) | HCID 10772950 | — |
| Reactant | HCID 86606010 | HCID 86606010 | — |
| Solvent | dichloromethane N,N-dimethylformamide | HCID 22350042 | — |
| Product | HCID 178507513 | HCID 178507513 | — |
Reaction Steps
N-(2-Aminophenyl)-2-(2-anilino-4-oxo-4,5-dihydro-1,3-thiazol-5-yl)acetic acid, prepared using method 2 above, (30 mg, 1 eq) was dissolved in a mixture of DCM/DMF (2 mL/2 mL) and O-phenylenediamine (15 mg, 1.1 eq), and 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (EDC, 30 mg, 1.3 eq) were then added sequentially. The reaction mixture was stirred 40° C. for 2 h. Separated between DCM and H2O, the organic layer concentrated to give a crude orange brown oil used directly in the next step: HPLC 43%, RT=0.93 min (System B, 2-95% MeCN over 2 min); MS [M+H]m/z=341.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08686011B2 |
|---|
| Source dataset | uspto-grants-2014_04 |
|---|
| ORD ID | ord-b2b8ab5a22db4330bfe611a787f2bcb3 |
|---|
| Source note | uspto-grants-2014_04 |
|---|
