Aminoacetonitrile → HCID 46197437, compound

Participants

Reaction Steps

General procedure F was used to couple 0.1 g (0.42 mmols) of 2 and 0.065 g of amino acetonitrile. The title product was purified with flash chromatography using a solvent system of ethyl acetate and hexanes (2:3) to yield 0.104 g (0.38 mmols). 1H NMR (300 MHz, CDCl3) δ 7.70 (d, J=8.3, 2H), 7.25 (d, J=7.6, 2H), 6.78 (t, J=5.5, 1H), 4.37 (d, J=5.8, 2H), 2.81-2.51 (m, 2H), 1.62 (dt, J=7.4, 22.1, 3H), 1.26 (s, 10H), 0.87 (t, J=6.7, 3H). 13C NMR (75 MHz, CDCl3) δ 167.32, 148.82, 130.03, 129.08, 127.46, 117.30, 77.67, 77.25, 76.83, 36.09, 32.06, 31.35, 29.62, 29.44, 28.19, 22.86, 14.31.

Provenance & Evidence