4-Bromo-2,6-difluoroaniline → HCID 66997295, compound

HRID 2360404Notes

Reaction equation

HRID 2360404 reaction equation
[F:1][C:2]1[CH:8]=[C:7](Br)[CH:6]=[C:5]([F:10])[C:3]=1[NH2:4].[Cl:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1B(O)O>>[Cl:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[C:7]1[CH:8]=[C:2]([F:1])[C:3]([NH2:4])=[C:5]([F:10])[CH:6]=1

Participants

3

Reactant 2

HCID 6101914-Bromo-2,6-difluoroanilineHCID 27343222-Chlorophenylboronic acid

Product 1

HCID 66997295HCID 66997295, compoundYield 55.1%

Procedure

The title compound (0.140 g) was prepared from 2,6-difluoro-4-bromo aniline (0.22 g, 1.06 mmol) and 2-chlorophenylboronic acid (0.21 g, 1.38 mmol) as a white solid. 1H-NMR (δ ppm, DMSO-d6, 400 MHz): 7.52-7.50 (m, 1H), 7.40-7.35 (m, 3H), 7.00 (d, J 2.1, 7.6, 2H), 5.39 (s, 2H).

Sources & evidence

ORD record
ord-cd61582650814c1c8271edf7ab22ae2e
Source dataset
uspto-grants-2014_04
Patent number
US08686048B2

Reaction notes

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