HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2,6-difluoroaniline → 3,5-Difluoro-3′-(trifluoromethoxy)[1,1′-biphenyl]-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2,6-difluoroaniline | HCID 610191 | — |
| Reactant | 3-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) | HCID 2734385 | — |
| Product | 3,5-Difluoro-3′-(trifluoromethoxy)[1,1′-biphenyl]-4-amine | HCID 66997725 | 58.5% |
Reaction Steps
The title compound (0.812 g) was prepared from 2,6-difluoro-4-bromo aniline (1 g, 4.8 mmol) and 3-(trifluoromethoxy)phenylboronic acid (1.28 g, 6.24 mmol) as a colourless liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08686048B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-5e293dc4c3da4c1aa2b494b41a4fa1e2 |
| Source note | uspto-grants-2014_04 |