3-Butoxyphenylboronic Acid → HCID 66997578, compound

HRID 2360419Notes

Reaction equation

HRID 2360419 reaction equation
Br[C:2]1[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([Cl:10])[CH:3]=1.[CH2:11]([O:15][C:16]1[CH:17]=[C:18](B(O)O)[CH:19]=[CH:20][CH:21]=1)[CH2:12][CH2:13][CH3:14]>>[CH2:11]([O:15][C:16]1[CH:21]=[C:20]([C:2]2[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([Cl:10])[CH:3]=2)[CH:19]=[CH:18][CH:17]=1)[CH2:12][CH2:13][CH3:14]

Participants

3

Reactant 2

HCID 50841013-Butoxyphenylboronic AcidHCID 204346204-Bromo-2-chloro-6-fluoroaniline

Product 1

HCID 66997578HCID 66997578, compoundYield 72.7%

Procedure

The title compound (0.190 g) was prepared from 4-bromo-2-chloro-6-fluoroaniline (0.2 g, 0.89 mmol) and 3-butoxyphenylboronic acid (0.224 g, 1.16 mmol) as a yellow solid. 1H-NMR (δ ppm, DMSO-d6, 400 MHz): 7.44-7.41 (m, 2H), 7.27 (t, J 7.9, 1H), 7.17-7.10 (m, 2H), 6.81-6.84 (m, 1H), 5.50 (s, 2H), 4.01 (t, J 5.3, 2H), 1.72-1.65 (m, 2H), 1.50-1.41 (m, 2H), 0.93 (t, J 7.4, 3H).

Sources & evidence

ORD record
ord-e04d672b99f34b1788a3aa6934378f5d
Source dataset
uspto-grants-2014_04
Patent number
US08686048B2

Reaction notes

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