4-Bromo-2,6-difluoroaniline → HCID 66997173, compound

HRID 2360424Notes

Reaction equation

HRID 2360424 reaction equation
Br[C:2]1[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([F:10])[CH:3]=1.[CH2:11]([O:15][C:16]1[CH:17]=[C:18](B(O)O)[CH:19]=[CH:20][CH:21]=1)[CH2:12][CH2:13][CH3:14]>>[F:10][C:4]1[CH:3]=[C:2]([C:20]2[CH:19]=[CH:18][CH:17]=[C:16]([O:15][CH2:11][CH2:12][CH2:13][CH3:14])[CH:21]=2)[CH:8]=[C:7]([F:9])[C:5]=1[NH2:6]

Participants

3

Reactant 2

HCID 6101914-Bromo-2,6-difluoroanilineHCID 50841013-Butoxyphenylboronic Acid

Product 1

HCID 66997173HCID 66997173, compoundYield 39.1%

Procedure

The title compound (0.104 g) was prepared from 4-bromo-2,6-difluoroaniline (0.2 g, 0.96 mmol) and 3-butoxyphenylboronic acid (0.242 g, 1.2 mmol) as a colourless liquid.

Sources & evidence

ORD record
ord-4da15393c18a43f6b1475d2cec7148fe
Source dataset
uspto-grants-2014_04
Patent number
US08686048B2

Reaction notes

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