(3-Chloro-5-methoxyphenyl)boronic acid → HCID 66997401, compound

HRID 2360434Notes

Reaction equation

HRID 2360434 reaction equation
Br[C:2]1[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([Cl:10])[CH:3]=1.[Cl:11][C:12]1[CH:13]=[C:14](B(O)O)[CH:15]=[C:16]([O:18][CH3:19])[CH:17]=1>>[Cl:10][C:4]1[CH:3]=[C:2]([C:14]2[CH:15]=[C:16]([O:18][CH3:19])[CH:17]=[C:12]([Cl:11])[CH:13]=2)[CH:8]=[C:7]([F:9])[C:5]=1[NH2:6]

Participants

3

Reactant 2

HCID 17750234(3-Chloro-5-methoxyphenyl)boronic acidHCID 204346204-Bromo-2-chloro-6-fluoroaniline

Product 1

HCID 66997401HCID 66997401, compoundYield 32.6%

Procedure

The title compound (41 mg) was prepared from 4-bromo-2-chloro-6-fluoroaniline (100 mg, 0.44 mmol) and 3-chloro-5-methoxyphenylboronic acid (107 mg, 0.57 mmol) as a pale-yellow solid.

Sources & evidence

ORD record
ord-4d95705b0d674effb43341ff4b521027
Source dataset
uspto-grants-2014_04
Patent number
US08686048B2

Reaction notes

Loading…