3,4-Dimethoxyphenylboronic acid → HCID 66997247, compound

HRID 2360439Notes

Reaction equation

HRID 2360439 reaction equation
Br[C:2]1[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([Cl:10])[CH:3]=1.[CH3:11][O:12][C:13]1[CH:14]=[C:15](B(O)O)[CH:16]=[CH:17][C:18]=1[O:19][CH3:20]>>[Cl:10][C:4]1[CH:3]=[C:2]([C:16]2[CH:15]=[CH:14][C:13]([O:12][CH3:11])=[C:18]([O:19][CH3:20])[CH:17]=2)[CH:8]=[C:7]([F:9])[C:5]=1[NH2:6]

Participants

3

Reactant 2

HCID 27347023,4-Dimethoxyphenylboronic acidHCID 204346204-Bromo-2-chloro-6-fluoroaniline

Product 1

HCID 66997247HCID 66997247, compoundYield 31.3%

Procedure

The title compound (39 mg) was prepared from 4-bromo-2-chloro-6-fluoroaniline (100 mg, 0.442 mmol) and 3,4-dimethoxyphenylboronic acid (80 mg, 0.62 mmol) as a pale-yellow solid.

Sources & evidence

ORD record
ord-40d44f6de1754070be87e64bbb266b0e
Source dataset
uspto-grants-2014_04
Patent number
US08686048B2

Reaction notes

Loading…