(2-Chloro-5-methoxyphenyl)boronic acid → HCID 66997739, compound

HRID 2360440Notes

Reaction equation

HRID 2360440 reaction equation
Br[C:2]1[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([Cl:10])[CH:3]=1.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][C:13]=1B(O)O>>[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][C:13]=1[C:2]1[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([Cl:10])[CH:3]=1

Participants

3

Reactant 2

HCID 17750233(2-Chloro-5-methoxyphenyl)boronic acidHCID 204346204-Bromo-2-chloro-6-fluoroaniline

Product 1

HCID 66997739HCID 66997739, compoundYield 31%

Procedure

The title compound (39 mg) was prepared from 4-bromo-2-chloro-6-fluoroaniline (100 mg, 0.44 mmol) and 2-chloro-5-methoxyphenylboronic acid (106 mg, 0.62 mmol) as a pale-yellow solid.

Sources & evidence

ORD record
ord-1fbc6e7422254eb7bfb1880c3885fc48
Source dataset
uspto-grants-2014_04
Patent number
US08686048B2

Reaction notes

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