4-Bromo-2,6-difluoroaniline → HCID 66997616, compound

HRID 2360441Notes

Reaction equation

HRID 2360441 reaction equation
Br[C:2]1[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([F:10])[CH:3]=1.[F:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][C:13]=1B(O)O>>[F:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][C:13]=1[C:2]1[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([F:10])[CH:3]=1

Participants

3

Reactant 2

HCID 6101914-Bromo-2,6-difluoroanilineHCID 41572112-Fluoro-5-methoxyphenylboronic acid

Product 1

HCID 66997616HCID 66997616, compoundYield 25.5%

Procedure

The title compound (31 mg) was prepared from 4-bromo-2,6-difluoroaniline (100 mg, 0.48 mmol) and 2-fluoro-5-methoxyphenylboronic acid (106 mg, 0.62 mmol) as a pale-yellow solid.

Sources & evidence

ORD record
ord-0f39d3471daa42fdb6cb9b0448482e15
Source dataset
uspto-grants-2014_04
Patent number
US08686048B2

Reaction notes

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