4-Bromo-2,6-difluoroaniline → HCID 66997637, compound

HRID 2360442Notes

Reaction equation

HRID 2360442 reaction equation
Br[C:2]1[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([F:10])[CH:3]=1.[Cl:11][C:12]1[C:17]([O:18][CH3:19])=[CH:16][C:15](B(O)O)=[CH:14][CH:13]=1>>[Cl:11][C:12]1[CH:13]=[CH:14][C:15]([C:2]2[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([F:10])[CH:3]=2)=[CH:16][C:17]=1[O:18][CH3:19]

Participants

3

Reactant 2

HCID 6101914-Bromo-2,6-difluoroanilineHCID 23005377(4-Chloro-3-methoxyphenyl)boronic acid

Product 1

HCID 66997637HCID 66997637, compoundYield 62.6%

Procedure

The title compound (81 mg) was prepared from 4-bromo-2,6-difluoroaniline (100 mg, 0.48 mmol) and 4-chloro-5-methoxyphenylboronic acid (116 mg, 0.62 mmol) as a white solid.

Sources & evidence

ORD record
ord-0f8f694ddd634bb282ee29811dfbab94
Source dataset
uspto-grants-2014_04
Patent number
US08686048B2

Reaction notes

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