4-Bromo-2-chloro-6-fluoroaniline → HCID 66997647, compound

HRID 2360443Notes

Reaction equation

HRID 2360443 reaction equation
Br[C:2]1[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([Cl:10])[CH:3]=1.[Cl:11][C:12]1[C:17]([O:18][CH3:19])=[CH:16][C:15](B(O)O)=[CH:14][CH:13]=1>>[Cl:10][C:4]1[CH:3]=[C:2]([C:15]2[CH:14]=[CH:13][C:12]([Cl:11])=[C:17]([O:18][CH3:19])[CH:16]=2)[CH:8]=[C:7]([F:9])[C:5]=1[NH2:6]

Participants

3

Reactant 2

HCID 204346204-Bromo-2-chloro-6-fluoroanilineHCID 23005377(4-Chloro-3-methoxyphenyl)boronic acid

Product 1

HCID 66997647HCID 66997647, compoundYield 65.1%

Procedure

The title compound (82 mg) was prepared from 4-bromo-2-chloro-6-fluoroaniline (100 mg, 0.44 mmol) and 4-chloro-5-methoxyphenylboronic acid (107 mg, 0.62 mmol) as a pale-yellow solid.

Sources & evidence

ORD record
ord-9be909edb50d40c0a704926c12d0ec15
Source dataset
uspto-grants-2014_04
Patent number
US08686048B2

Reaction notes

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