4-Bromo-2,6-difluoroaniline → HCID 66997348, compound

HRID 2360445Notes

Reaction equation

HRID 2360445 reaction equation
Br[C:2]1[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([F:10])[CH:3]=1.[F:11][C:12]1[C:17]([O:18][CH3:19])=[CH:16][C:15](B(O)O)=[CH:14][CH:13]=1>>[F:10][C:4]1[CH:3]=[C:2]([C:15]2[CH:14]=[CH:13][C:12]([F:11])=[C:17]([O:18][CH3:19])[CH:16]=2)[CH:8]=[C:7]([F:9])[C:5]=1[NH2:6]

Participants

3

Reactant 2

HCID 6101914-Bromo-2,6-difluoroanilineHCID 44558185(4-Fluoro-3-methoxyphenyl)boronic acid

Product 1

HCID 66997348HCID 66997348, compoundYield 197.5%

Procedure

The title compound (480 mg) was prepared from 4-bromo-2,6-difluoroaniline (200 mg, 0.96 mmol) and 4-fluoro-5-methoxyphenylboronic acid (210 mg, 1.24 mmol) as a white solid. 1H-NMR (δ ppm, DMSO-d6, 400 MHz): 7.39-7.29 (m, 3H), 7.21-7.12 (m, 2H), 5.33 (s, 2H), 3.90 (s, 3H).

Sources & evidence

ORD record
ord-fdaf048d665b4d20ac83fa5c6e99b2e1
Source dataset
uspto-grants-2014_04
Patent number
US08686048B2

Reaction notes

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