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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2360449Generated: October 31, 2026

4-Bromo-2-chloro-6-fluoroaniline → HCID 66996801, compound

https://huagongshe.com/reaction/2360449

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Bromo-2-chloro-6-fluoroanilineHCID 20434620—
Reactant[3-(2,2,2-Trifluoroethoxy)phenyl]boronic acidHCID 43145319—
ProductHCID 66996801HCID 6699680160.4%

Reaction Steps

The title compound (85 mg) was prepared from 4-bromo-2-chloro-6-fluoroaniline (100 mg, 0.44 mmol) and 3-(2,2,2-trifluoroethoxy)phenylboronic acid (127 mg, 0.57 mmol) as a white solid. 1H-NMR (δ ppm, DMSO-d6, 400 MHz): 7.53-7.44 (m, 2H), 7.38-7.26 (m, 3H), 6.94 (d, J 7, 1H), 5.55 (s, 2H), 4.83 (q, J 8.9, 2H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08686048B2
Source datasetuspto-grants-2014_04
ORD IDord-66f3b2adc0b2486ba27df7dbe05d1eeb
Source noteuspto-grants-2014_04