4-Bromo-2,6-difluoroaniline → HCID 66997723, compound

HRID 2360453Notes

Reaction equation

HRID 2360453 reaction equation
Br[C:2]1[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([F:10])[CH:3]=1.[CH:11]1([O:14][C:15]2[CH:16]=[C:17](B3OC(C)(C)C(C)(C)O3)[CH:18]=[CH:19][CH:20]=2)[CH2:13][CH2:12]1>>[CH:11]1([O:14][C:15]2[CH:20]=[C:19]([C:2]3[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([F:10])[CH:3]=3)[CH:18]=[CH:17][CH:16]=2)[CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 6101914-Bromo-2,6-difluoroanilineHCID 574676352-[3-(Cyclopropyloxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Product 1

HCID 66997723HCID 66997723, compoundYield 11.3%

Procedure

The title compound (170 mg) was prepared from 4-bromo-2,6-difluoroaniline (1.2 g, 5.76 mmol) and 2-(3-cyclopropoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1.5 g, 5.76 mmol) as a yellow liquid.

Sources & evidence

ORD record
ord-c975c85140864a0e9a9aa3ee6f4f5e51
Source dataset
uspto-grants-2014_04
Patent number
US08686048B2

Reaction notes

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