4-Bromo-3-fluoroaniline → HCID 66997694, compound

HRID 2360455Notes

Reaction equation

HRID 2360455 reaction equation
Br[C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[F:9].[Cl:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][C:12]=1B(O)O>>[Cl:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][C:12]=1[C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[F:9]

Participants

3

Reactant 2

HCID 8218484-Bromo-3-fluoroanilineHCID 17750233(2-Chloro-5-methoxyphenyl)boronic acid

Product 1

HCID 66997694HCID 66997694, compoundYield 92.7%

Procedure

The title compound (280 mg) was prepared from 4-bromo-3-fluoroaniline (227 mg, 1.2 mmol) and 2-chloro-5-methoxyphenylboronic acid (290 mg, 1.6 mmol) as a pale-yellow liquid.

Sources & evidence

ORD record
ord-e494009a656142dda45596bd7dbc19bd
Source dataset
uspto-grants-2014_04
Patent number
US08686048B2

Reaction notes

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