4-Bromo-2,6-difluoroaniline → HCID 66997744, compound

HRID 2360459Notes

Reaction equation

HRID 2360459 reaction equation
Br[C:2]1[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([F:10])[CH:3]=1.[F:11][C:12]([F:25])([F:24])[CH2:13][O:14][C:15]1[CH:16]=[C:17](B(O)O)[CH:18]=[CH:19][CH:20]=1>>[F:10][C:4]1[CH:3]=[C:2]([C:17]2[CH:18]=[CH:19][CH:20]=[C:15]([O:14][CH2:13][C:12]([F:11])([F:24])[F:25])[CH:16]=2)[CH:8]=[C:7]([F:9])[C:5]=1[NH2:6]

Participants

3

Reactant 2

HCID 6101914-Bromo-2,6-difluoroanilineHCID 43145319[3-(2,2,2-Trifluoroethoxy)phenyl]boronic acid

Product 1

HCID 66997744HCID 66997744, compoundYield 77.2%

Procedure

The title compound (89 mg) was prepared from 4-bromo-2,6-difluoroaniline (80 mg, 0.38 mmol) and 3-(2,2,2-trifluoroethoxy)phenylboronic acid (108 mg, 0.5 mmol) as a colourless liquid.

Sources & evidence

ORD record
ord-d14e98803fc641e0b2e6a923f6c5216e
Source dataset
uspto-grants-2014_04
Patent number
US08686048B2

Reaction notes

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